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Enzymes like Acyl-CoA synthetase long-chain family member 4 (ACSL4) and lysophosphatidylcholine acyltransferase 3 (LPCAT3) are instrumental in PE biosynthesis, activating PUFAs and modulating their transmembrane dynamics [140]
doi: 10.1111/j.1365-2125.2011.04070.x
Based on preclinical and limited clinical studies, berberine's primary metabolic effects appear to occur through activation of AMP-activated protein kinase (AMPK), an enzyme that serves as a cellular energy sensor
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